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Untargeted LC–MS/MS analysis reveals metabolomics feature of osteosarcoma stem cell response to methotrexate

机译：未标准的LC-MS / MS分析显示骨肉瘤干细胞对甲氨蝶呤的代谢组特征

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摘要

Spherical colonies (sarcospheres) generated from single-cell suspensions of OS cells cultured in serum-free medium supplemented with growth factors in non-adherent conditions. OS cells gradually aggregated and formed tumor spheres (Original magnification: 200 ×)

机译：由在无粘附条件下补充有生长因子的无血清培养基中培养的OS细胞的单细胞悬浮液产生的球形菌落（SARCHESHERE）。 OS细胞逐渐聚集和形成肿瘤球体（原始倍率：200×）

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期刊名称 Cancer Cell International
作者
Feng Wang; Zhiyu Zhang; Qin Li; Tao Yu; Chengbin Ma;
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作者单位

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年(卷),期 2020(-1),-1
年度 2020
页码 -1
总页数 16
原文格式 PDF
正文语种
中图分类肿瘤学;
关键词

机译：骨肉瘤（OS）;癌症干细胞（CSC）;化学抗性;代谢组学;甲氨蝶呤（MTX）;

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专利

1. Untargeted LC–MS/MS analysis reveals metabolomics feature of osteosarcoma stem cell response to methotrexate [J] . Feng Wang, Zhiyu Zhang, Qin Li, Cancer Cell International . 2020,第1期

机译：未标准的LC-MS / MS分析显示骨肉瘤干细胞对甲氨蝶呤的代谢组特征
2. Untargeted metabolomic analysis using LC-TOF/MS and LC-MS/MS for revealing metabolic alterations linked to alcohol-induced hepatic steatosis in rat serum and plasma [J] . Wu Huan, Feng Fang RSC Advances . 2016,第34期

机译：使用LC-TOF / MS和LC-MS / MS进行非靶向代谢组学分析，以揭示与酒精诱导的大鼠血清和血浆肝脂肪变性相关的代谢变化
3. Untargeted metabolomic analysis using LC-TOF/MS and LC-MS/MS for revealing metabolic alterations linked to alcohol-induced hepatic steatosis in rat serum and plasma [J] . Huan Wu, Fang Feng RSC Advances . 2016,第34期

机译：使用LC-TOF / MS和LC-MS / MS的未出现的代谢组分，用于揭示与大鼠血清和血浆中的酒精诱导的肝脏脂肪变性相关的代谢改变
4. A Stress Response Comparison: LC/MS metabolomics analysis of Saccharomyces cerevisiae exposed to the immunosuppressant drugs FK506 and Cyclosporin A [C] . Stefan Jenkins, Theodore R. Sana, Lily Chen American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2010

机译：应力响应比较：LC / MS代谢组科分析酿酒酵母暴露于免疫抑制药物FK506和环孢菌素A.
5. Metabolomic Analysis of Bacterial Cell Wall Intermediates Using LC-MS/MS: Peptidoglycan Pathway Response to Different Antibiotics. [D] . Vemula, Harika. 2017

机译：使用LC-MS / MS对细菌细胞壁中间体进行代谢组学分析：肽聚糖途径对不同抗生素的反应。
6. Corrigendum to ‘LC-MS metabolomics comparisons of cancer cell and macrophage responses to methotrexate and polymer-encapsulated methotrexate’ International Journal of Pharmaceutics: X Volume 1 (2019) 100036 [O] . Mohammad Ahmad Al-Natour, Ali Alazzo, Amir M. Ghaemmaghami, 2020

机译：癌细胞和巨噬细胞对甲氨蝶呤和聚合物包封甲氨蝶呤的癌细胞和巨噬细胞反应的勘探性勘误表国际药物学报：X卷1（2019）100036
7. Untargeted LC–MS/MS analysis reveals metabolomics feature of osteosarcoma stem cell response to methotrexate [O] . Feng Wang, Zhiyu Zhang, Qin Li, 2020

机译：未标准的LC-MS / MS分析显示骨肉瘤干细胞对甲氨蝶呤的代谢组特征
8. Metabolomic Analysis of the Secretome of Human Embryonic Stem Cells Following Methyl Parathion and Methyl Paraoxon Exposure. Phase 3. LC-MS-MS Structural Confirmation. [R] . Madren-Whalley, J. S., Sekowski, J. W., Palmer, J. A., 2014

机译：甲基对硫磷和甲基对氧磷暴露后人胚胎干细胞分泌组的代谢组学分析。阶段3.LC-ms-ms结构确认。

Untargeted LC–MS/MS analysis reveals metabolomics feature of osteosarcoma stem cell response to methotrexate

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