Comparative transcriptome analysis of Parkinson’s disease and Hutchinson-Gilford progeria syndrome reveals shared susceptible cellular network processes

摘要

Parkinson’s disease (PD) is one of the most common neurodegenerative disorders, with approximately 10 million affected persons worldwide [1]. Despite major advances in understanding PD genetics, no preventive or disease-modifying therapy is available [2]. Several studies have linked PD with aging-related cellular processes [3–5], showing that PD and aging share molecular hallmarks such as neuroinflammation [6], impaired DNA repair [7] and mitochondrial dysfunction [8]. Furthermore, PD has been hypothesized to represent an accelerated or premature form of aging, due to molecular changes that resemble aging-associated alterations but progress faster and/or occur earlier [3, 9, 10].