LINC02418 promotes malignant behaviors in lung adenocarcinoma cells by sponging miR-4677-3p to upregulate KNL1 expression

摘要

The biological function of LINC02418 in LAD. a Heatmap showing highly expressed LINC02418 in LAD. b LINC02418 expression in LAD cell lines and normal pulmonary epithelial cell line was examined by RT-qPCR. c The transfection efficiency of sh-LINC02418#1 and sh-LINC02418#2 in A549 and SPC-A1 cells were measured by RT-qPCR. d CCK-8 assay was performed to assess cell proliferation of A549 and SPC-A1 cells after the knockdown of LINC02418. e Colony formation assay was carried out to detect the proliferation of A549 and SPC-A1 cells in response to LINC02418 knockdown. f Transwell assay was applied to access cell migration in A549 and SPC-A1 cells after downregulation LINC02418. g Western blot was used to examine the level of migration-related proteins after knocking down LINC02418. **P < 0.01