Association of the calcitriol to calcifediol ratio with cardiac involvement in newly diagnosed sarcoidosis

摘要

Vitamin D (VitD), a well-known regulator of calcium- and phosphate-metabolism has been shown to influence many non-skeletal conditions, including sarcoidosis and cardiovascular diseases; decreasing levels of vitamin are correlated with increased mortality1. In sarcoidosis (Sa), granuloma-derived interferon-gamma (among others) stimulates the production - and expresses to a high degree - one alpha hydroxylase, the enzyme that drives hydroxylation of 25(OH)D3 (calcifediol) to 1,25(OH)2D3 (calcitriol). The 1,25(OH)2D3/25(OH)D3 ratio (VDR) may reflect the efficiency of vitamin D hydroxylase activity 2. A possible association between VitD metabolites and VDR with Sa severity has not been adequately evaluated. Cardiac involvement in Sa impairs prognosis, even with preserved left ventricular ejection fraction (EF). The aim of this study was to evaluate serum 1,25(OH)2D3, 25(OH)D3 and VDR vis-à-vis myocardial involvement in Sa.