Buffer composition to catalyze the preparation of calcitriol or calcifediol and method to prepare calcitriol or calcifediol using this

摘要

Buffer composition to promote the production of calcitriol or calcifediol consisting of 0.01 to 0.3% (w / v) of at least one metal compound selected from the group consisting of FeCl2, FeCl3, FeSO4, MnCl2, and ZnSO4 1 to 10% (w / v) of at least one organic solvent selected from the group consisting of ethanol, methanol, acetone, and dimethylsulfoxide (DMSO), 0.1 to 5% (w / v) of cyclodextrin, 0.01 at 1% (w / v) of tris (hydroxymethyl) aminomethane, 0.01 to 1% (w / v) of sodium succinate, 0.01 to 1% (w / v) of sodium chloride, 0.001 to 0, 5% (w / v) magnesium chloride, and a residual amount of water.