Real-time Continuous Glucose Monitoring During a Hyperinsulinemic-Hypoglycemic Clamp Significantly Underestimates the Degree of Hypoglycemia

摘要

Real-time continuous glucose monitoring (rtCGM) is increasingly used in patients with type 1 diabetes because it provides real-time data with low glucose alarms in place to alert individuals or their carers to developing hypoglycemia. This technology may be especially useful for those with impaired awareness of hypoglycemia (IAH). However, there is limited reported evidence on the accuracy of these devices in the hypoglycemic range in these patients under controlled conditions (1). In an ongoing clinical study of people with type 1 diabetes and IAH we compared data collected from rtCGM with time-matched arterialized venous (AV) blood analyzed using a bedside plasma glucose analyzer and a standard blood glucose meter (used in self-monitoring of blood glucose [SMBG]) under experimental hypoglycemic conditions.