Multi-omic and multi-species meta-analyses of nicotine consumption

摘要

Schematic of analytical pipeline used for cross-species analysis. Panels indicate:1) Derivation of gene list using genes associated with nicotine exposure from various animal paradigms. 2) Multicomponent SNP-heritability analysis in UKBiobank smokers using mixed linear models. 3) Examination of gene-list overlap using Jaccard similarity and Fisher exact tests. 4) Multicomponent polygenic score analysis using GWAS-LOCO summary statistics in an independent sample.