A Preclinical Model to Analyze the Oncological Safety of Fat Grafting in Breasts With Residual Cancer in Immunocompetent Hosts

摘要

INTRODUCTION: Preclinical studies (PS) aiming to evaluate the microenvironment of breast cancer (BC) is very important for analysis of risk and the behavior of this disease to treatments proposed in humans, such as fat grafting to the breast (FGB). These studies, however, present serious methodological problems. They are based on models that use cancer-induced carcinogens that have a residual systemic effect or through the use of nonluminal human BC implanted in immunosuppressed murine hosts. Thus, this study objectives to analyze the effectiveness of cafeteria diet (CD) to trigger BC and yield enough fat for autologous grafting, in order to create a preclinical model able to analyze oncological safety of FGB in immunocompetent hosts.