Diversity-oriented synthesis derived indole based spiro and fused small molecules kills artemisinin-resistant

摘要

Screening of DOS-synthesised compounds for anti-plasmodial activity. a Synchronized parasite culture in ring stage were seeded to adjust parasitaemia to 1%. This synchronized culture was then treated either with DMSO or compounds (5 µM) for 48 h. Giemsa-stained slides were prepared at 0 and 48 h post-treatment to monitor the parasitaemia. Graphs were prepared for the average value of three independent experiments performed in duplicate with ± SD. b Parasites at different stages of the IDC at 0 and 48 h post-treatment were calculated. Table shows the percentage of remaining parasites in different stages of IDC from three independent experiments with ± SD