The interplay of UBE2T and Mule in regulating Wnt/β-catenin activation to promote hepatocellular carcinoma progression

摘要

a An integrative analysis of three publicly available datasets, CSCdB, TCGA (LIHC), and {"type":"entrez-geo","attrs":{"text":"GSE5975","term_id":"5975"}}GSE5975, was performed to search for genes that were commonly upregulated between liver cancer cells and liver CSCs compared to normal liver cells. A Venn diagram analysis showed that a total of 2026 genes were commonly upregulated. b GO analysis of these 2026 genes with BiNGO followed by clustering with AutoAnnotate revealed enrichment of DNA replication and repair pathways. c Within the replication and repair pathway, the interstrand cross-link repair pathway had the highest and most significant fold enrichment. d Upon DEseq2 analysis, UBE2T was the most significantly upregulated gene among 19 genes in the interstrand cross-link repair pathway.