Reduced O-GlcNAcylation of SNAP-23 promotes cisplatin resistance by inducing exosome secretion in ovarian cancer

摘要

A The morphology and size of exosomes in control and OGT-deficient cells were detected by TEM. Scale bars represent 100 nm. B, C The size distribution (B) and number (C) of two groups measured by NTA. D Western blotting analysis was used to test exosome markers CD63 and HSP70. The values are presented as mean ± SD (n = 3), which were three separate experiments performed in triplicate. **P < 0.01, *P < 0.05 (Student’s t test).