METHOD FOR SUPPRESSING CISPLATIN-RESISTANCE USING NRF2 INTERFERENCE RNA WHICH RECOVERS CISPLATIN SENSITIVITY IN HUMAN OVARIAN CANCER CELL LINE SK-OV

摘要

PURPOSE: A method for suppressing cisplatin resistance using Nrf2 interference RNA is provided to ensure anti-cancer activity of Nrf2-deficient cell in treating a cisplatin.;CONSTITUTION: A method for suppressing resistance of cisplatin of anti-cancer drug through Nrf2 interference RNA is to suppress the transcription of Nrf2 (NF-E2-related factor 2) which protects cells from ROS (reactive oxygen species). The suppression of resistance of cisplatin through interference RNA has significant sensitivity in human ovarian cancer cell line SK-OV.;COPYRIGHT KIPO 2010