CircRNA PIP5K1A promotes the progression of glioma through upregulation of the TCF12/PI3K/AKT pathway by sponging miR-515-5p

摘要

CircPIP5K1A expression in normal and cancerous tissues of glioma. a RT-PCR was used to verify the CircPIP5K1A expression in the tumorous and adjacent normal tissues. ***P < 0.0001. b RT-PCR was adopted to determine the circPIP5K1A expression in normal glioma cells HEB and tumor cell lines (U87, TJ861, TJ905, U251, H4, and A172), *P < 0.05, ***P < 0.001 vs. HEB group. c KM plotter was used for analyzing the relationship between circPIP5K1A expression with glioma prognosis. d CircPIP5K1A and GAPDH levels by RT-PCR in total cellular RNA incubated with RNase R