Experimental observation of the sequence of tibial plateau chondrocyte and matrix degeneration in spontaneous osteoarthritis in Guinea pigs

摘要

Comparison of sequences of chondrocyte and extracellular matrix degeneration in cartilage tissue. a, b Comparisons of safranin O staining patterns of knee tibial plateau cartilage tissue and OARSI scores, IHC results of the Aggrecan,CollagenX,MMP-13 and Caspase-3 proteins and IHC scores. Comparison of serum concentration of CTX-II. Scale = 100 μm. Statistical significance is shown for One-way ANOVA. Bars represent the mean ± SEM, *p < 0.05 compared with the 8-month-old group and #p < 0.05 compared with the 10-month-old group