Updated risk-oriented strategy for acute lymphoblastic leukemia in adult patients 18–65 years: NILG ALL 10/07

摘要

Study patients with Ph− ALL were risk stratified, randomized to IT CNS prophylaxis, and HLA-typed for the search for suitable HCT donors. Patients who achieved CR and were eligible for early allogeneic HCT displayed either a very HR (VHR) profile and/or TP2 MRD ≥ 10−4 or were HR without MRD results. Other SR and HR patients were allocated to maintenance chemotherapy when testing TP2-3 MRD negative (MRDneg) and to allogeneic HCT when testing MRD positive (MRDpos).