Does Intravenous or Intraarticular Tranexamic Acid (TXA) Reduce Joint Bleeding Following Arthroscopic Anterior Cruciate Ligament (ACL) Reconstruction and Arthroscopic Meniscectomy? Can Intraarticular Use be Harmful to Chondrocytes?

摘要

Knee arthroscopy to carry out partial removal of the meniscus and reconstruction of the anterior cruciate ligament (ACL) is common and efficacious, albeit a potential adverse event is intraarticular bleed after surgery. When this adverse event takes place, besides the concomitant pain, the patient commonly needs a joint aspiration (arthrocentesis) to avert loss of range of motion (ROM). Occasionally this problem leads to a poor result of surgery as a result of loss of ROM. That is why the utilization of tranexamic acid (TXA) has been taken into account with the aim of diminishing postoperative hemarthrosis and its potential associated adverse events (1–3).