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Effects of tumour necrosis factor on cardiovascular disease and cancer: A two-sample Mendelian randomization study

机译：肿瘤坏死因子对心血管疾病和癌症的影响：两种样品孟德尔随机化研究

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摘要

Tumour necrosis factor (TNF) inhibitors are used in the treatment of certain autoimmune diseases but given the role of TNF in tumour biology and atherosclerosis, such therapies may influence the risk of cancer and cardiovascular disease. We conducted a Mendelian randomization study to explore whether TNF levels are causally related to cardiovascular disease and cancer.

机译：肿瘤坏死因子（TNF）抑制剂用于治疗某些自身免疫疾病，但鉴于TNF在肿瘤生物学和动脉粥样硬化中的作用，这种疗法可能影响癌症和心血管疾病的风险。我们进行了孟德尔随机化研究，探讨TNF水平是否因心血管疾病和癌症而导致。

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期刊名称 EBioMedicine
作者
Shuai Yuan; Paul Carter; Maria Bruzelius; Mathew Vithayathil; Siddhartha Kar; Amy M. Mason; Ang Lin; Stephen Burgess; Susanna C. Larsson;
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年(卷),期 2020(59),-1
年度 2020
页码 -1
总页数 8
原文格式 PDF
正文语种
中图分类
关键词
Cancer; Cardiovascular disease; Tumour necrosis factor;

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专利

1. Effects of tumour necrosis factor on cardiovascular disease and cancer: A two-sample Mendelian randomization study [J] . Shuai Yuan, Paul Carter, Maria Bruzelius, EBioMedicine . 2020,第6期

机译：肿瘤坏死因子对心血管疾病和癌症的影响：两种样品孟德尔随机化研究
2. Association of Autism Spectrum Disorder, Neuroticism, and Subjective Well-Being With Cardiovascular Diseases: A Two-Sample Mendelian Randomization Study [J] . Xingang Sun, Lu Chen, Zhen Wang, Frontiers in Cardiovascular Medicine . 2021,第a期

机译：自闭症谱系障碍，神经细胞和主观福祉与心血管疾病的关联：一种双样本孟德尔随机化研究
3. Causal effects of cardiovascular risk factors on onset of major age-related diseases: A time-to-event Mendelian randomization study [J] . He Liang, Culminskaya Irina, Loika Yury, Experimental Gerontology . 2018,第期

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4. Ketosis, Tumor Necrosis Factor-a and Cardiovascular Disease in Type-1 Diabetic Patients [C] . Sushil K. Jain, Robert Mcvie, Joseph A. Bocchini, International Society for Heart Research.Congress . 2003

机译：1型糖尿病患者的酮症，肿瘤坏死因子-A和心血管疾病
5. A comprehensive dose -response study of the effects of pistachios on cardiovascular disease risk factors: A translational research approach integrating clinical nutrition and molecular biology [D] . Gebauer, Sarah K. 2008

机译：开心果对心血管疾病危险因素影响的全面剂量反应研究：结合临床营养和分子生物学的转化研究方法
6. Causal Effects of Genetically Predicted Cardiovascular Risk Factors on Chronic Kidney Disease: A Two-Sample Mendelian Randomization Study [O] . Hui-Min Liu, Qin Hu, Qiang Zhang, 2013

机译：基因预测的心血管危险因素对慢性肾脏疾病的因果影响：孟德尔随机抽样的两样本研究
7. Causal Effects of Genetically Predicted Cardiovascular Risk Factors on Chronic Kidney Disease: A Two-Sample Mendelian Randomization Study [O] . Hui-Min Liu, Qin Hu, Qiang Zhang, 2019

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Effects of tumour necrosis factor on cardiovascular disease and cancer: A two-sample Mendelian randomization study

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