The mammalian small intestine exhibits a remarkable capacity for renewal during homeostasis and regeneration after injury. This capacity is powered by stem cells, which give rise to cells committed to executing the absorptive or secretory functions of the epithelium. I will discuss two studies using live imaging of organoids to understand the mechanisms that organize stem cells, secretory cells, and absorptive cells into the precise patterns required for tissue function. These studies reveal how cells integrate spatial and mechanical cues with fate decisions to precisely replace lost material during regeneration and renewal.
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