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Transcriptomic analysis across liver diseases reveals disease-modulating activation of constitutive androstane receptor in cholestasis

机译：肝脏疾病的转录组分析显示胆汁淤积中构成androstane受体的疾病调制激活

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摘要

Liver diseases are caused by many factors, such as genetics, nutrition, and viruses. Therefore, it is important to delineate transcriptomic changes that occur in various liver diseases.

机译：肝脏疾病是由许多因素引起的，例如遗传，营养和病毒。因此，划定在各种肝脏疾病中发生的转录组变化很重要。

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期刊名称 JHEP Reports
作者
Bhoomika Mathur; Waqar Arif; Megan E. Patton; Rahiman Faiyaz; Jian Liu; Jennifer Yeh; Sanjiv Harpavat; Kristina Schoonjans; Auinash Kalsotra; Antony M. Wheatley; Sayeepriyadarshini Anakk;
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年(卷),期 2020(2),5
年度 2020
页码 -1
总页数 13
原文格式 PDF
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中图分类
关键词
Bile acids; Cholestasis; Cytochrome p450; Drug metabolism; Liver diseases; Nuclear receptors; Transcriptomics;

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专利

1. Mode of action and human relevance analysis for nuclear receptor-mediated liver toxicity: A case study with phenobarbital as a model constitutive androstane receptor (CAR) activator [J] . Elcombe Clifford R., Peffer Richard C., Wolf Douglas C., Critical reviews in toxicology . 2014,第1a10期

机译：核受体介导的肝毒性的作用方式和人类相关性分析：以苯巴比妥为模型组成型雄激素受体（CAR）激活剂的案例研究
2. Mode of action and human relevance analysis for nuclear receptor-mediated liver toxicity: A case study with phenobarbital as a model constitutive androstane receptor (CAR) activator [J] . Elcombe Clifford R., Peffer Richard C., Wolf Douglas C., Critical reviews in toxicology . 2014,第1a10期

机译：核受体介导的肝毒性的作用方式和人体相关性分析 - 以苯巴比妥作为模型本构androstane受体（轿车）活化剂的案例研究
3. Induction of mouse UDP-glucuronosyltransferase mRNA expression in liver and intestine by activators of aryl-hydrocarbon receptor, constitutive androstane receptor, pregnane X receptor, peroxisome proliferator-activated receptor alpha, and nuclear fac [J] . Buckley DB, Klaassen CD Drug Metabolism and Disposition: The Biological Fate of Chemicals . 2009,第4期

机译：芳烃受体，组成型雄甾烷受体，孕烷X受体，过氧化物酶体增殖物激活受体α和核因子的激活剂诱导小鼠UDP和葡萄糖醛酸转移酶mRNA在肝脏和肠道中的表达
4. Direct activation of Constitutive Androstane Receptor by Phthalates [C] . Haishan LI, Wenchao AI, Hui HAN, International Conference on Biological Engineering and Pharmacy . 2017

机译：通过邻苯二甲酸酯直接激活组成型和rostane受体
5. Novel human Constitutive Androstane Receptor Activators and their Effects on Hepatic Energy Homeostasis. [D] . Lynch, Caitlin. 2014

机译：新型人类组成型雄激素受体激活剂及其对肝能量稳态的影响。
6. β-Defensin 1 Is Prominent in the Liver and Induced During Cholestasis by Bilirubin and Bile Acids via Farnesoid X Receptor and Constitutive Androstane Receptor [O] . Thomas Klag, Maria Thomas, Dirk Ehmann, -1

机译：β-防御素1在肝中突出在胆汁淤积过程中被胆红素和胆汁酸通过法呢类X受体和组成型雄激素受体诱导。
7. Transcriptomic analysis across liver diseases reveals disease-modulating activation of constitutive androstane receptor in cholestasis [O] . Bhoomika Mathur, Waqar Arif, Megan E. Patton, 2020

机译：肝脏疾病的转录组分析显示胆汁淤积中构成androstane受体的疾病调制激活
8. Endosulfan-alpha Induces CYP26 and CYP3A4 by Activating the Pregnane X Receptor But Not the Constitutive Androstane Receptor [R] . Casabar, R. C. 2006

机译：硫丹-α通过激活孕烷X受体而不是组成型雄甾烷受体诱导CYp26和CYp3a4

Transcriptomic analysis across liver diseases reveals disease-modulating activation of constitutive androstane receptor in cholestasis

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