SIX AUTHORS REPLY

摘要

We thank the for the opportunity to respond to Young ( ) regarding our study of acrylonitrile exposure and all-cause and cause-specific mortality ( ). In his letter, Young introduces the extraneous issue of multiple testing when, in fact, multiple testing is not an issue. Instead, our a priori hypothesis was that acrylonitrile was associated with increased lung cancer mortality. This hypothesis was based on results from previous studies, including the first follow-up of the National Cancer Institute cohort, which suggested a positive association between acrylonitrile exposure and lung cancer ( ). Thus, the curious counting of all tests by Young is not relevant to the specific result of an association between acrylonitrile and the targeted outcome of lung cancer. Because there was a single primary hypothesis, the issue of multiple testing is moot.