MYC functions as a switch for natural killer cell-mediated immune surveillance of lymphoid malignancies

摘要

– viSNE of CyTOF data depicting splenic CD3 T ( ), splenic CD4 T ( ), CD8a T ( ), NKp46 NK ( ) and CD19 B ( ) cell compositions of one representative mouse from normal (  = 11), (  = 9) and (doxycycline 96 h,  = 10) groups. – Quantification of absolute counts of total WBC ( ), immature CD3 CD8 CD4 DP lymphoma T cells ( ), CD3 NKp46 mature NK ( ) and CD19 B ( ) cells in normal (  = 11), (  = 9) and (doxycycline 96 h,  = 10) mice subjected to CyTOF. Median fluorescence intensity (MFI) of NKp46 on splenic NK cells from normal (  = 11), (  = 9) and (doxycycline 96 h,  = 10) mice. Schematic depicting the reversible phenomenon of NK cell (blue) suppression in MYC-driven lymphomas (red). -values have been calculated using a two-sided Mann–Whitney test. ns not significant. For all box plots, the center is at the median, minima and maxima are indicated by whiskers, and the box represents data between the 25th and 75th percentile.