Mitochondrial outer membrane β-barrel proteins are synthesized in the cytosol (yellow), then imported into the intermembrane space of the mitochondria by the translocase of the outer membrane complex (TOM complex, green). Once in the intermembrane space, the precursor protein is bound by chaperone proteins (TIM9/10, magenta/cyan) and directed to the sorting and assembly machinery complex (SAM complex, blue/light green/orchid). The SAM complex facilitates outer membrane β-barrel precursor protein folding and insertion into the outer membrane.
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