AFAP1‐AS1: A novel oncogenic long non‐coding RNA in human cancers

摘要

Long non‐coding s (lnc s), a group of non‐protein‐coding s with more than 200 nucleotides in length, are involved in multiple biological processes, such as the proliferation, apoptosis, migration and invasion. Moreover, numerous studies have shown that lnc s play important roles as oncogenes or tumour suppressor genes in human cancers. In this paper, we concentrate on actin filament‐associated protein 1‐antisense 1 ( ), a well‐known long non‐coding that is overexpressed in various tumour tissues and cell lines, including oesophageal cancer, pancreatic ductal adenocarcinoma, nasopharyngeal carcinoma, lung cancer, hepatocellular carcinoma, ovarian cancer, colorectal cancer, biliary tract cancer and gastric cancer. Moreover, high expression of was associated with the clinicopathological features and cancer progression. In this review, we sum up the current studies on the characteristics of in the biological function and mechanism of human cancers.