LINC00473 antagonizes the tumour suppressor miR‐195 to mediate the pathogenesis of Wilms tumour via IKKα

摘要

Although dramatic improvements of overall survival has achieved in patients with favourable histology Wilms tumour, disease recurrence is still the main cause of cancer‐related death in childhood. Long non‐coding s (lnc s) as oncogenes or tumour suppressors are dysregulated during carcinogenesis. However, the role of lnc s in the pathogenesis of Wilms tumour is unknown. Here, an lnc 00473 signature that functioned as oncogene was identified in Wilms tumour.