Determination of Voriconazole Concentrations in Serum by GC‐MS

摘要

Voriconazole is a broad spectrum triazole antifungal drug used to treat systemic fungal infections. Therapeutic drug monitoring of voriconazole is necessary for achieving maximal efficiency without inducing toxic side effects. Other publications have reported methods for measuring voriconazole in serum using high‐performance liquid chromatography (HPLC) and liquid chromatography tandem mass spectrometry (LC‐MS/MS). Here, we report for the first time a method for the measurement of voriconazole in serum samples using gas chromatography mass spectrometry (GC‐MS).