A low cost and input tailing method of quality control on multiple annealing and looping‐based amplification cycles‐based whole‐genome amplification products

摘要

Single‐cell whole‐genome sequencing provides novel insights into the nature of genetic heterogeneity in normal and diseased cells. However, amplification of formalin‐fixed tissues with low cell numbers is still problematic and multiple annealing, and looping‐based amplification cycles (MALBAC) is a commonly used whole‐genome amplification (WGA) method with low cell numbers.