Predisposed genomic instability in pre-treatment bone marrow evolves to therapy-related myeloid neoplasms in malignant lymphoma

摘要

Therapy-related myeloid neoplasm (tMN) occurs as a late complication of cytotoxic chemotherapy and/or radiation therapy. Approximately 30% of all tMN occur in patients with a previous hematologic malignancy, mostly malignant lymphomas (ML). ML patients are likely to receive multiple types of chemotherapy and hence, the underlying developmental mechanism of tMN remains elusive.