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A Randomized Double-Blinded Placebo-Controlled Dose-Escalation Phase 1 Study of Aerosolized Pirfenidone Delivered via the PARI Investigational eFlow Nebulizer in Volunteers and Patients with Idiopathic Pulmonary Fibrosis

机译：随机双盲安慰剂对照剂量递增的阶段性研究通过PARI研究性eFlow雾化器在志愿者和特发性肺纤维化患者中雾化吡非尼酮

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摘要

This clinical trial evaluated the pharmacokinetics and safety/tolerability of inhaled pirfenidone solution in volunteers and patients with idiopathic pulmonary fibrosis (IPF).

机译：该临床试验评估了吸入性吡非尼酮溶液在志愿者和特发性肺纤维化（IPF）患者中的药代动力学和安全性/耐受性。

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期刊名称 Journal of Aerosol Medicine and Pulmonary Drug Delivery
作者
Jun Keng Khoo; A. Bruce Montgomery; Kelly L. Otto; Mark Surber; Jessica Faggian; Jason D. Lickliter; Ian Glaspole;
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作者单位

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年(卷),期 -1(33),1
年度 -1
页码 -1
总页数 6
原文格式 PDF
正文语种
中图分类呼吸生理学;
关键词
aerosol delivery; BAL; ELF concentrations; idiopathic pulmonary fibrosis; pirfenidone; vibrating plate nebulizer;

机译：气雾剂输送;BAL;ELF浓度;特发性肺纤维化;吡非尼酮;振动板雾化器;

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1. A Randomized, Double-Blinded, Placebo-Controlled, Dose-Escalation Phase 1 Study of Aerosolized Pirfenidone Delivered via the PARI Investigational eFlow Nebulizer in Volunteers and Patients with Idiopathic Pulmonary Fibrosis [J] . Khoo Jun Keng, Montgomery A. Bruce, Otto Kelly L., Journal of aerosol medicine and pulmonary drug delivery . 2020,第1期

机译：通过在志愿者和特发性肺纤维化患者中通过Pari Invelationational Eflow Jabulizer提供的随机，双盲，安慰剂控制的剂量升级的剂量升级阶段1研究。
2. A Randomized Double-Blind Placebo-Controlled Dose-Escalation Phase 1 Study of Aerosolized Amikacin and Fosfomycin Delivered via the PARI Investigational eFlow((R)) Inline Nebulizer System in Mechanically Ventilated Patients [J] . Robinson Paul Journal of aerosol medicine and pulmonary drug delivery . 2014,第6期

机译：通过PARI研究性eFlow（R）在线雾化器系统在机械通气患者中进行的雾化阿米卡星和磷霉素随机双盲安慰剂控制剂量递增1期研究
3. A Randomized Double-Blind Placebo-Controlled Dose-Escalation Phase 1 Study of Aerosolized Amikacin and Fosfomycin Delivered via the PARI Investigational eFlow (R) Inline Nebulizer System in Mechanically Ventilated Patients [J] . Montgomery A. Bruce, Vallance Shirley, Abuan Tammy, Journal of aerosol medicine and pulmonary drug delivery . 2014,第6期

机译：通过机械通气患者的PARI研究性eFlow（R）在线雾化器系统递送的雾化阿米卡星和磷霉素的随机双盲安慰剂控制剂量递增阶段1研究
4. A Randomized Double-Blind Placebo-Controlled Dose-Escalation Phase 1 Study of Aerosolized Amikacin and Fosfomycin Delivered via the PARI Investigational eFlow® Inline Nebulizer System in Mechanically Ventilated Patients [O] . A. Bruce Montgomery, Shirley Vallance, Tammy Abuan, -1

机译：机械通气患者中通过PARIeFlow®在线雾化器系统递送的雾化阿米卡星和磷霉素的随机双盲安慰剂控制剂量递增阶段1研究
5. A Randomized, Double-Blinded, Placebo-Controlled, Dose-Escalation Phase 1 Study of Aerosolized Pirfenidone Delivered via the PARI Investigational eFlow Nebulizer in Volunteers and Patients with Idiopathic Pulmonary Fibrosis [O] . Jun Keng Khoo, A. Bruce Montgomery, Kelly L. Otto, 2020

机译：随机，双盲，安慰剂控制的剂量升级阶段1研究通过志愿者和特发性肺纤维化患者的Pari Invelatigational Eflow Jabulizer输送的雾化皮里酮。

A Randomized Double-Blinded Placebo-Controlled Dose-Escalation Phase 1 Study of Aerosolized Pirfenidone Delivered via the PARI Investigational eFlow Nebulizer in Volunteers and Patients with Idiopathic Pulmonary Fibrosis

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