Cognition- and circuit-based dysfunction in a mouse model of 22q11.2 microdeletion syndrome: effects of stress

摘要

Gambling task comparing differences in probabilistic learning based decision making under uncertainty in Wt and Df(h22q11)/+ mice. Graph represents the average percentage of advantageous arms ± SEM of different subgroups of Wt and Df(h22q11)/+ mice during the gambling task over 10 days. The animals were divided into safe or risky groups based on their choice for advantageous over chance level (denoted by dashed lines). The box denotes performance of animals over the last 3 days that were used for statistical analysis. Statistical difference from chance level: *  #  §  b Attention set shifting task showing poor cognitive flexibility of Df(h22q11)/+ mice in the extra dimensional set shifting (EDS) task. Mixed bars/scatter plots represent the number of trials to criterion of six consecutive correct trials (±SEM) for each discrimination task for Wt and Df(h22q11)/+ mice during the attention set shifting paradigm (*  c Y maze task: impaired short-term spatial memory in Df(h22q11)/+ mice. Mixed bars/scatter plots represent the number of alternate arm entries relative to the total number of arm entries after a delay of 1 h (left) and the number of spontaneous alternate arm entries relative to the total number of arm entries (right) for both Wt and Df(h22q11)/+ mice (*