S30. COMBINING PHARMACOTHERAPY OF BI 425809 WITH COMPUTERIZED COGNITIVE TRAINING IN PATIENTS WITH SCHIZOPHRENIA: A RANDOMIZED TRIAL METHODOLOGY

摘要

Trials of pharmacotherapies targeting cognition in schizophrenia have produced mainly negative results, and there are no approved cognition-enhancing pharmacological treatments available for patients with schizophrenia. This may be due in part to varying levels of concurrent cognitive stimulation, particularly for pharmacotherapies targeting neuroplasticity, which is activity-dependent (i.e. responds to cognitive demand). Often, the surroundings and environment of patients with schizophrenia provide only a low level of cognitive demand. At-home computerized cognitive training (CCT) can be one way to increase the level of environmental cognitive stimulation for these patients.