IRF4 and STAT3 activities are associated with the imbalanced differentiation of T-cells in responses to inhalable particulate matters

摘要

Peripheral blood mononuclear cell (PBMC) expression profiling in a healthy population reveals co-expressed gene modules in association with PM exposure. , enrollment of healthy subjects from three cities in north China, Beijing, Taiyuan and Shijiazhuang; , Three-week average exposure level (μg/m ) of PM (left) and PM (right) of each enrolled subject from the three cities; , PBMC gene expression profile generated from the enrolled subjects; , 18 co-expressed gene modules retrieved from the PBMC gene expression profiles with correlation coefficients to the exposure levels of five major pollutants shown heat colors and , integrating DNA motif, transcription factor activity and KEGG pathway to infer transcription factors underlying the co-expressed gene modules (*  P P