Hippocampal transcriptome analysis following maternal separation implicates altered RNA processing in a mouse model of fetal alcohol spectrum disorder

摘要

Module formation and trait association using weighted gene co-expression network analysis (WGCNA). Hierarchical clustering dendrogram of module eigengenes with the dissimilarity of eigengenes given by 1-(eigengene correlation) and module-trait correlation heatmap for 11 traits: prenatal or postnatal treatment, experimental group (group), Barnes maze learning score (learningscore), weight at postnatal day 21 (p21weight), open field test activity (OFTactivity), distance (OFTdistance), latency to enter the center (OFTlatency), number of center entries (OFTentries), home cage activity (HCactivity), and number of rears (HCrears), with positive (red) and negative (blue) correlations, with the number of significantly ( < 0.05) positively or negatively correlated modules with each trait indicated