PLC 1 MUTANT ANIMAL MODEL FOR TESTING MATERNAL BEHAVIOR OR PATERNAL ATTENTIVENESS, AND SCREENING METHOD FOR AGENT FOR TREATING OR PREVENTING THE DISORDER OF MATERNAL BEHAVIOR OR PATERNAL ATTENTIVENESS USING SAID ANIMAL MODEL

摘要

The present invention relates to an animal model system enabling the investigation of paternal attentiveness of a male mouse, by using, as a mate, a female mouse from which phospholipase C1 gene is knocked out. More specifically, the present invention relates to a mating system enabling the investigation, in various male mice, on a response associated with an increase in compensational paternal attentiveness induced by maternal attentiveness disorder of the knock-out female mice. According to the genetic animal model of the present invention, it is possible to provide a bad mother (or a neglecting mother) environment required for the biological investigation on paternal attentiveness in non-biparental species, without artificial manipulation such as chemical treatment or isolation.