Arsenic sulfide induces RAG1-dependent DNA damage for cell killing by inhibiting NFATc3 in gastric cancer cells

摘要

NFATc3 silencing inhibits viability and proliferation of gastric cancer cell line. Immunoblot and the cell growth of AGS ( ), MGC803 ( ), and MKN45 ( ) cells infected by the indicated lentiviral vectors. Cell cycle profiling of the indicated AGS cells ( ). Stacked barplot shows the fraction of cells viable in G1, S and G2/M phases of the indicated cells ( ) (The percentage of cell population at each phases are represented as mean ± S.D. of three independent experiments). NFATc3 expression in shC3–1 and the derivative line expressing the shC3–1- resistant NFATc3. Fold changes relative to first line are indicated. The proliferation of the indicated AGS cells for 6 days. Statistical significance was assessed using two-way ANOVA. *  p p