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Surgical Fixation of Metacarpal Shaft Fractures Using Absorbable Implants: A Systematic Review of the Literature

机译:使用可吸收植入物的掌骨干骨折的外科手术固定:文献的系统评价

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摘要

Despite the proven efficacy and advantages of absorbable implants, their use for metacarpal shaft fixation has been limited. This is likely due to the high reported complication rates in early studies with polyglycolic acid (PGA) implants, notably high rates of noninfectious inflammatory reaction (5%-25%), occurring up to 30 weeks after fixation. The objective of this study was to assess the clinical outcomes of newer absorbable plates and screws in the treatment of metacarpal shaft fractures. The authors performed a systematic search of the PubMed, Ovid MEDLINE, and EMBASE databases dating from 1946 to 2017. Primary outcome measures were the development of noninfectious inflammatory reaction and implant failure. A total of 42 metacarpal shaft fractures in 35 patients were included. The average follow-up time was 20.4 months (n = 24; range: 3.6-61 months). Only 1 case (2.4%) of noninfectious inflammatory reaction was reported with polylactic acid (PLA) plates and PLA/PGA compounds. Noninfectious inflammatory reaction was observed in 4 out of the 9 patients (44.4%) with a trimethylene carbonate/PLA compound. Symptoms appeared after an average time of 15.8 months (range: 12-19 months) post-fixation. Painless prolonged inflammation that resolved spontaneously within 6 months was reported in 7.1% of cases (n = 3). Implant failure with loss of fracture reduction was reported in 9.5% of cases (n = 4). Newer absorbable materials appear to have significantly lower rates of noninfectious inflammatory reaction than previously reported. When compared with metallic fixation of the metacarpal shaft, absorbable fixation appears to have comparable complication rates and biomechanical properties.
机译:尽管已证实可吸收植入物的功效和优点,但其在掌骨干固定中的应用受到限制。这可能是由于早期关于聚乙醇酸(PGA)植入物的报道的并发症发生率很高,特别是在固定后长达30周的非感染性炎症反应发生率很高(5%-25%)。这项研究的目的是评估较新的可吸收钢板和螺钉在掌骨干骨折治疗中的临床效果。作者对1946年至2017年的PubMed,Ovid MEDLINE和EMBASE数据库进行了系统搜索。主要结果指标是非感染性炎症反应的发生和植入失败。总共包括35例患者的42掌骨干骨折。平均随访时间为20.4个月(n = 24;范围:3.6-61个月)。聚乳酸(PLA)板和PLA / PGA化合物仅报告1例(2.4%)非感染性炎症反应。 9名碳酸三亚甲基酯/ PLA化合物患者中有4名(44.4%)观察到非感染性炎症反应。固定后平均时间为15.8个月(范围:12-19个月)后出现症状。在7.1%的病例中报告了6个月内无痛,自发缓解的长时间炎症(n = 3)。在9.5%的病例中报告了种植失败并伴有骨折复位失败(n = 4)。较之以前报道,较新的可吸收材料似乎具有较低的非感染性炎症反应速率。与掌骨干的金属固定相比,可吸收固定似乎具有可比的并发症发生率和生物力学特性。

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