Gastroesophageal reflux disease (GERD) is the most common esophageal disorder, affecting more than 20 % of the population worldwide. GERD symptoms vary from simple heartburn and epigastric pain to more complex clinical situations, with a combination of other various extra-esophageal symptoms that include hoarseness, odynophagia, chronic cough, pharyngitis and laryngitis, asthma, disrupted sleep, chronic bronchitis and pneumonia.
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