Endoscopic gastric plication for the treatment of GERD and underlying class I obesity

摘要

GERD is a common gastrointestinal disorder that affects approximately 25% of the U.S. population. 1 Several studies have demonstrated a higher prevalence of GERD in patients with obesity compared to those with a normal body mass index (BMI). 2 Specifically, a gain of at least 3.5 kg/m 2 in BMI is associated with a 3-fold increase in rates of GERD compared with those with a stable BMI. 3 Potential mechanisms include an increase in intragastric pressure, transient relaxations of the lower esophageal sphincter, prevalence of hiatal hernia, esophageal dysmotility, and a decrease in lower esophageal sphincter pressure in patients with obesity.