A method of treating a gastrointestinal motility disorder, a gerd treatment, a night gerd treatment, a pharmaceutical composition, a kit comprising a compound and a method for increasing esophageal motility in a patient.

摘要

"METHOD OF TREATMENT OF A GASTRINTESTINAL MOBILITY DISTURBANCE, 'GERD' TREATMENT OF NIGHT 'GERD', PHARMACEUTICAL COMPOSITION, KIT UNDERSTANDING A COMPOUND AND METHOD TO INCREASE A PATIENT MOTIBILITY." The present invention relates to the method of treating a gastrointestinal motility disorder in a patient in need of treatment comprising co-administering to said patient a first amount of a compound having 5-HT 3 receptor agonist activity. or a pharmaceutically acceptable salt hydrate or solvate thereof; and a second amount of at least one gastric acid suppressing agent (for example, a proton pump inhibitor, a H 2 -receptor antagonist or a pharmaceutically acceptable salt, hydrate or solvate thereof, or a pharmaceutically acceptable acid or salt pump, hydrate or solvate thereof), wherein the first and second amounts together comprise a therapeutically effective amount. In particular, the method is for treating GERD, including nocturnal GERD. The invention further relates to a method of treating nocturnal GERD which comprises administering to a patient in need thereof a therapeutically effective amount of a compound which is endowed with 5-HT 3 receptor agonist activity OR a salt, pharmaceutically acceptable hydrate or solvate thereof. The invention further relates to a method for increasing esophageal motility in a patient in need thereof. The method for enhancing esophageal motility may be achieved by administering a compound which is endowed with 5-HT 3 receptor agonist activity or a pharmaceutically acceptable salt, hydrate or solvate thereof. Coadministration may also be used to increase esophageal motility.