The conserved DNMT1-dependent methylation regions in human cells are vulnerable to neurotoxicant rotenone exposure

摘要

Characterization of conserved DNMT1-dependent regions in the Human genome. The percent span of the DNMT1-dependent regions in mouse covered by the identified human conserved regions. Pie chart represents the percentage of all identified conserved regions in the human genome that fall into each category. The percent base-pair match of the DNMT1-dependent regions in mouse with the identified human conserved regions. Pie chart represents the percentage of all conserved regions in the human genome that fall into each category. The percentage of all conserved regions in the human genome that are located within the promoter, the gene body, or in non-coding intergenic regions. The top transcription factor binding sites found within all human conserved regions. The percentage of known germline ASMs in our conserved DNMT1-dependent regions separated by genome