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Design Synthesis and Biological Evaluation of New HDAC1 and HDAC2 Inhibitors Endowed with Ligustrazine as a Novel Cap Moiety

机译：川gust嗪作为新型帽部分的新型HDAC1和HDAC2抑制剂的设计合成和生物学评估

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Histone deacetylases (HDACs) represent one of the most validated cancer targets. The inhibition of HDACs has been proven to be a successful strategy for the development of novel anticancer candidates.

机译：组蛋白脱乙酰基酶（HDAC）代表最有效的癌症靶标之一。已经证明，抑制HDAC是开发新型抗癌候选物的成功策略。

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期刊名称 Drug Design Development and Therapy
作者
Mohammad M Al-Sanea; Lizaveta Gotina; Mamdouh FA Mohamed; Della Grace Thomas Parambi; Hesham A M Gomaa; Bijo Mathew; Bahaa G M Youssif; Khalid Saad Alharbi; Zainab M Elsayed; Mohamed A Abdelgawad; Wagdy M Eldehna;
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作者单位

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年(卷),期 2020(14),-1
年度 2020
页码 -1
总页数 12
原文格式 PDF
正文语种
中图分类药学;药物化学;
关键词
HDACs Inhibitors; Ligustrazine; Anticancer agents; In silico study; Synthesis;

机译：HDACs抑制剂川gust嗪抗癌剂计算机研究合成;

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专利

1. Design, Synthesis and Biological Evaluation of New HDAC1 and HDAC2 Inhibitors Endowed with Ligustrazine as a Novel Cap Moiety [J] . Mohammad M Al-Sanea, Lizaveta Gotina, Mamdouh FA Mohamed, Drug Design, Development and Therapy . 2020,第1期

机译：新的HDAC1和HDAC2抑制剂的设计，合成和生物学评价，赋予Ligustrazine作为一种新型帽部分
2. Design, synthesis and biological evaluation of novel histone deacetylase1/2 (HDAC1/2) and cyclin-dependent Kinase2 (CDK2) dual inhibitors against malignant cancer [J] . European Journal of Medicinal Chemistry: Chimie Therapeutique . 2020,第期

机译：新型组蛋白脱乙酰酶的设计，合成和生物学评价，对恶性癌症的新组蛋白脱乙酰酶1/2（HDAC1 / 2）和细胞周期蛋白依赖性激酶2（CDK2）双抑制剂
3. Design, synthesis, and biological evaluation of quinazoline derivatives as dual HDAC1 and HDAC6 inhibitors for the treatment of cancer [J] . Chen Jinying, Sang Zitai, Jiang Youjun, Chemical biology and drug design . 2019,第3期

机译：喹唑啉衍生物作为双HDAC1和HDAC6抑制剂治疗癌症的设计，合成和生物学评价
4. Design, Synthesis, and Biological Evaluation of Nedd4 E3 Ubiquitin Ligase Small Molecule Inhibitors [C] . Xiaoli Fu, Jie Chu, Yuyin Li, International conference on applied biotechnology . 2014

机译：Nedd4 E3泛素连接酶小分子抑制剂的设计，合成和生物学评估
5. Design and synthesis of molecular probes to modulate cell membrane permeation: I. Design, synthesis, and biological evaluation of novel chicoric acid analogues as inhibitors of HIV-1 integrase. II. Design, synthesis, and biological evaluation of novel estradiol analogues targeting the membrane estrogen receptor. [D] . Charvat, Trevor Thomas. 2004

机译：设计和合成的分子探针，可调节细胞膜的渗透性：I.设计，合成和生物评价作为抗HIV-1整合酶抑制剂的新型菊苣酸类似物。二。针对膜雌激素受体的新型雌二醇类似物的设计，合成和生物学评估。
6. A New CDK2 Inhibitor with 3-Hydrazonoindolin-2-One Scaffold Endowed with Anti-Breast Cancer Activity: Design Synthesis Biological Evaluation and In Silico Insights [O] . Mohammad M. Al-Sanea, Ahmad J. Obaidullah, Mohamed E. Shaker, 2021

机译：一种新的CDK2抑制剂具有3-肼吲哚啉-2-ONE支架赋予抗乳腺癌活动：设计合成生物评估以及硅洞察力
7. >Design, Synthesis and Biological Evaluation of New HDAC1 and HDAC2 Inhibitors Endowed with Ligustrazine as a Novel Cap Moiety [O] . Mohammad AlSanea, Lizaveta Gotina, Mamdouh F.A. Mohamed, 2020

机译：>新的HDAC1和HDAC2抑制剂的设计，合成和生物学评价，赋予Ligustrazine作为新型帽部分

Design Synthesis and Biological Evaluation of New HDAC1 and HDAC2 Inhibitors Endowed with Ligustrazine as a Novel Cap Moiety

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