iMTBGO: An Algorithm for Integrating Metabolic Networks with Transcriptomes Based on Gene Ontology Analysis

摘要

Constraint-based metabolic network models have been widely used in pheno-typic prediction and metabolic engineering design. In recent years, researchers have attempted to im-prove prediction accuracy by integrating regulatory information and multiple types of “omics” data into this constraint-based model. The transcriptome is the most commonly used data type in integration, and a large number of FBA (flux balance analysis)-based integrated algorithms have been developed.