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Joule heating-induced particle manipulation on a microfluidic chip

机译:焦耳热诱导的微流控芯片上的粒子处理

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摘要

We develop an electrokinetic technique that continuously manipulates colloidal particles to concentrate into patterned particulate groups in an energy efficient way, by exclusive harnessing of the intrinsic Joule heating effects. Our technique exploits the alternating current electrothermal flow phenomenon which is generated due to the interaction between non-uniform electric and thermal fields. Highly non-uniform electric field generates sharp temperature gradients by generating spatially-varying Joule heat that varies along the radial direction from a concentrated point hotspot. Sharp temperature gradients induce a local variation in electric properties which, in turn, generate a strong electrothermal vortex. The imposed fluid flow brings the colloidal particles at the centre of the hotspot and enables particle aggregation. Furthermore, maneuvering structures of the Joule heating spots, different patterns of particle clustering may be formed in a low power budget, thus opening up a new realm of on-chip particle manipulation process without necessitating a highly focused laser beam which is much complicated and demands higher power budget. This technique can find its use in Lab-on-a-chip devices to manipulate particle groups, including biological cells.
机译:我们开发了一种电动技术,通过独家利用固有的焦耳热效应,以节能的方式连续操纵胶体颗粒以浓缩成图案化的颗粒群。我们的技术利用了交流电热流现象,这种现象是由于不均匀的电场和热场之间的相互作用而产生的。高度不均匀的电场通过产生从集中点热点开始沿径向方向变化的空间变化的焦耳热,从而产生尖锐的温度梯度。急剧的温度梯度会引起电特性的局部变化,进而产生强烈的电热涡旋。施加的流体流将胶体颗粒带到热点的中心,并使颗粒聚集。此外,可以在低功率预算中形成焦耳加热点的操纵结构,不同的粒子簇模式,从而开辟了片上粒子操纵过程的新领域,而无需高度聚焦的激光束,这非常复杂且要求高。更高的功率预算。该技术可以在芯片实验室设备中使用,以操纵包括生物细胞在内的粒子群。

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