The Beneficial Effect of Eco-Friendly Green Nanoparticles Using Garcinia mangostana Peel Extract against Pathogenicity of Listeria monocytogenes in Female BALB/c Mice

摘要

is a resourceful foodborne pathogen triggering listeriosis. It was recently found that the bacterium caused acute and self-limiting delirious gastroenteritis in healthy individuals. In the intestinal tract, enters the mucosa directly via enterocytes. Animal models for infection have provided many insights into the mechanisms of pathogenesis, and the development of new model systems has allowed the investigation of factors that influence adaptation to the gastrointestinal environment. This study investigated that the oral administration of natural products in association with silver nanoparticles could inhibit oral infection of listeria in BALB/c mice. The effect of natural products biosynthesized silver nanoparticles (Ag-NPs) using peel extract were well-known as the major targets of oral listeria infection in mice. Anti-inflammatory factors are important to treat the dangers of chronic inflammation associated with chronic diseases. The pro-inflammatory cytokine levels, such as interleukin (IL)-1 beta and tumor necrosis factor (TNF)-alpha, decreased in the intestine of mice receiving Ag-NPs using peel extract. Therefore, the current study addresses the beneficial effect of the inflammation and apoptotic signaling pathways in intestine induced by .