Convenient synthesis of novel macrocyclic urethanes: alkoxycarbonylation of amines and ring-closing metathesis strategy

摘要

Alkoxycarbonylation of amines followed by ring-closing metathesis of the resulting dienes with Grubbs catalyst (25–50 mol%) provided convenient access to 14–16 membered macrocyclic urethanes in very good yields. 0 1998 Elsevier Science Ltd. All rights reserved.