Tedanolide C: a potent new 18-membered ring cytotoxic macrolide isolated from the Papua New Guinea marine sponge Ircinia sp

摘要

Cytotoxicity-guided fractionation of the crude methanol extract of a marine sponge, Ircinia sp., yielded tedanolide C (>1), a new 18-membered macrolide. The structure was solved by interpreting NMR and MS data, and the relative stereochemistry was determined from a combination of homo and heteronuclear coupling constants in conjunction with molecular modeling. Compound >1 exhibited potent cytotoxicity against HCT-116 cells in vitro. Cell cycle analysis showed that treatment of cells with compound >1 arrested cells in S-phase.