Practical Scalable High-Throughput Approaches to η3-Pyranyl and η3-Pyridinyl Organometallic Enantiomeric Scaffolds Using the Achmatowicz Reaction

摘要

A unified strategy for the high throughput synthesis of multigram quantities of the η³-oxopyranyl- and η³-oxopyridinylmolybdenum complexes TpMo(CO)2(η³-oxopyranyl) and TpMo(CO)2(η³-oxopyridinyl) is described (Tp = hydridotrispyrazolylborato). The strategy uses the oxa- and aza-Achmatowicz reaction for the preparation of these organometallic enantiomeric scaffolds, in both racemic and high enantiopurity versions.