Interleukin-1 inhibits osmotically-induced calcium signaling and volume regulation in articular chondrocytes

摘要

OBJECTIVEArticular chondrocytes respond to osmotic stress with transient changes in cell volume and the intracellular concentration of calcium ion ([Ca²⁺]i). The goal of this study was to examine the hypothesis that interleukin-1 (IL-1), a pro-inflammatory cytokine associated with osteoarthritis, influences osmotically-induced Ca²⁺ signaling.