Event Tracking Model of Adhesion Identifies Load-bearing Bonds in Rolling Leukocytes

摘要

ObjectivesP-selectin binding to P-selectin glycoprotein ligand (PSGL)-1 mediates leukocyte rolling under conditions of inflammation and injury. The objectives were to develop an efficient, high temporal resolution model for direct simulation of leukocyte rolling, and then to conduct a study of load-bearing bonds using the model.