Enhancement of Docetaxel Anti-cancer Activity by A Novel Diindolylmethane (DIM) Compound in Human Non-Small Cell Lung Cancer

摘要

PurposeThis study was conducted to examine the cytotoxic effects of a peroxisome proliferator-activated receptor γ (PPARγ) agonist, 1,1-bis (3′ indolyl)-1-(p-biphenyl) methane (DIM-C-pPhC6H5) alone and in combination with docetaxel (doc) in vitro in A549 lung cancer cells and in vivo in nude mice bearing A549 orthotopic lung tumors.