Soluble CD14 Levels Interleukin-6 and Mortality Among Prevalent Hemodialysis Patients

摘要

Background:CD14 is a pattern-recognition receptor that plays a central immunomodulatory role in pro-inflammatory signaling in response to a variety of ligands, including endotoxin. CD14 protein is present in two forms soluble (sCD14) and membrane-bound. Hereby we studied the implications of elevated sCD14 in hemodialysis patients. We hypothesized that sCD14 elevation may link to cytokine activation and protein-energy wasting, predisposing to increased mortality risk.